Genetic Lifehacks makes it easy to use your genetic data to find personalized health and wellness solutions.
- Learn how your genes influence your nutrition, longevity, and wellness.
- Every article shows your genotype report along with research-backed solutions.
- Decide what will work best for you.
Ad-free, science-driven information, empowering you to make informed decisions. Use your genetic raw data from 23andMe, AncestryDNA, and more.
What members are saying:
“Life Changing. Words can not express the gratitude and my mind is blown away at how many dots I was able to connect. The knowledge I have been gifted in learning is transformative and every human should be given a genetic test upon birth.”
~ Sarah J.
“Genetic Lifehacks provides relevant and actionnable information for both the layperson and practitioners. Debbie translates very complicated science into understandable concepts for all of us. I can’t recommend this service more highly.”
~ TJ H
“I LOVE LOVE LOVE this site! I show it to all of my medical providers. It’s awesome that it can combine your data from both 23&me and Ancestry DNA. It becomes a beautiful, well laid out, personal map of your own health.”
~ Theresa E.
Latest Articles and Genotype Reports:
Topic: Supplements & Genes
- DAO Enzyme Supplements: Research Studies and Genetic Connections
DAO enzyme supplements work by providing the enzyme needed to break down histamine in food and from the gut microbiome. - Which Type of Choline Works Best with Your Genes?
Choline is an often neglected nutrient essential to a healthy diet. Your genes are important in how much and which types of choline you need. - Sulforaphane: Studies, Genetic Connections
Overview of sulforaphane research studies, bioavailability, and genetic interactions. Learn about dosage, supplements, and natural sources.
Topic: Heart Health
- Salt Sensitivity and High Blood Pressure
Genetic variants significantly influence individual salt sensitivity, with certain genotypes making people more prone to high blood pressure in response to high salt intake - Homocysteine: Genetics, High Homocysteine Levels, and Solutions
High homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels. - Niacin and Heart Disease: Genetic Interaction
Higher intake of niacin, along with certain genetic variants, has been shown to increase the risk of heart disease. Check your SNPs here.
Topic: Inflammation / Immune Response
- Asthma Genes: Understanding your genetic pathways
Genes and environmental factors combine to cause asthma. Learn how your genes impact the pathways involved in the different types of asthma. - Red Light and Photobiomodulation: ATP from Photons
Red and near-infrared wavelengths of light interact with mitochondria to produce ATP. Learn why – and discover how mitochondrial genes may play a role. - Rosacea, Genetics, and Solutions
Rosacea is a chronic inflammatory skin condition that is driven by upregulated inflammation. Learn how your genes interact with environmental factors to cause rosacea.
Topic: Mood and Brain
- Schizophrenia: Genetic and Environmental Factors
Schizophrenia is a complex disease caused by a combination of genetic susceptibility along with environmental factors. Research points to multiple pathways involved in schizophrenia and schizoaffective disorder. - Highly Sensitive People: Genes, Brain Function, and Sensory Sensitivity
Genetic variants are linked to being a Highly Sensitive Person – feeling more deeply and more sensitive to environmental stimuli. - MAO-A and MAO-B: Neurotransmitter levels, genetics, and warrior gene studies
The MAOA and MAOB genes encode enzymes that break down certain neurotransmitters. People with low MAO may be prone to mood issues in certain circumstances.
Topic: Autoimmune Diseases
- HLA B27: Genetic Variant That Increases Susceptibility to Autoimmune Diseases
The HLA-B27 serotype is linked to an increased risk of several autoimmune diseases, including ankylosing spondylitis, psoriatic arthritis, and IBD. - Leaky Gut Genes: Emulsifiers in Processed Foods
Emulsifiers, found in many processed and packaged foods, can trigger an inflammatory response in the intestines based on whether you carry specific genetic variants. - Familial Mediterranean Fever: Mimics fibromyalgia, arthritis, inflammation
Familial Mediterranean fever (FMF) is a genetic condition of inflammatory episodes that cause painful joints, pain in the abdomen, or pain in the chest. It is most often accompanied by a fever. FMF is often misdiagnosed as various pain-related conditions such as fibromyalgia, myofascial pain syndrome, or gouty arthritis.
Topic: Methylation Cycle Genes
- AHCY Gene: Tying together methylation and homocysteine
AHCY is a key gene in the conversion of SAH to homocysteine and in the regulation of the SAM/SAH ratio. It also plays an important role in the circadian regulation of gene expression. - Homocysteine: Genetics, High Homocysteine Levels, and SolutionsHigh homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels.
- MTHFR Mutation: What is it? How to check your raw data.
The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants.
Topic: Mitochondrial Health
- Mold Genes: How mold and mycotoxins interact with genetics
Exposure to certain kinds of mold can cause chronic, negative health effects. Discover how genetic variants impact the ability to handle mycotoxins. - Creatine: Boosting Muscles and Increasing Brain Power
Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function. - Statins and Brain Fog: Exploring how statins impact memory and cognitive function
Understand the connection between statin use and brain fog. Dive into the research on how cholesterol-lowering drugs impact cognitive health and memory.
Topic: Disease Prevention
- Parkinson’s Disease: Genetics plus Environmental Factors
Parkinson’s disease (PD) is not yet fully understood. Researchers think that it is caused by a combo of genetics and environmental factors. Learn more about this disease and the factors that lead to susceptibility. - Gilbert’s Syndrome: A genetic disorder causing high bilirubin
Gilbert’s syndrome is an inherited condition where the body doesn’t break down bilirubin efficiently. Discover the benefits of higher bilirubin levels in this syndrome and some possible risks. - BH4: Tetrahydrobiopterin Synthesis, Recycling, and Genetic SNPs
Tetrahydrobiopterin (BH4) is an essential cofactor in the production of neurotransmitters and nitric oxide. Genetic variants impact BH4 levels which can affect heart disease, cognitive function, and immune response.
Topic: Detoxification & Medications
- Mold Genes: How mold and mycotoxins interact with geneticsExposure to certain kinds of mold can cause chronic, negative health effects. Discover how genetic variants impact the ability to handle mycotoxins.
- Glyphosate Exposure: Genetics and the Impact on Our Health
Glyphosate is the active ingredient in the herbicide Round-Up. A recent study showed that people with CYP1A1 genetic variants are more likely to have problems with acetylcholinesterase inhibition from glyphosate. - Phthalates: Genes, Detoxification, and Diet
Phthalates are a type of chemical used as plasticizers to make plastics more pliable. There has been a lot of research on the endocrine-disrupting effects of phthalates. Your genetic variants may impact whether phthalates are a problem for you.
Topic: Nutrigenomics – Vitamins and Diet
- Which Type of Choline Works Best with Your Genes?Choline is an often neglected nutrient essential to a healthy diet. Your genes are important in how much and which types of choline you need.
- AHCY Gene: Tying together methylation and homocysteineAHCY is a key gene in the conversion of SAH to homocysteine and in the regulation of the SAM/SAH ratio. It also plays an important role in the circadian regulation of gene expression.
- MTHFR Mutation: What is it? How to check your raw data.The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants.
Topic: Longevity / Healthspan
- Parkinson’s Disease: Genetics plus Environmental FactorsParkinson’s disease (PD) is not yet fully understood. Researchers think that it is caused by a combo of genetics and environmental factors. Learn more about this disease and the factors that lead to susceptibility.
- Nicotinamide Riboside and NMN: Boosting NAD+ in Aging
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process. - Taurine: Research on Healthspan and Supplements
Taking a deep dive into the science behind taurine – from antiaging supplement to heart and digestive health. Genetics plays a role in who may benefit most from supplemental taurine.
Topic: Circadian Rhythm and Sleep
- Melanopsin: Light response, circadian rhythm, and blue light exposure
Melanopsin is the receptor for blue light. It is found in the retina, skin, adipose tissue, and blood vessels. Genetic variants can impact reaction to blue light. - Histamine, Mast Cell Activation, and Early Morning Insomnia
Histamine rising in the early morning hours may cause early waking insomnia. Mast cells and circadian rhythm disruption at the root. - Restless Leg and Periodic Limb Movement Disorder: Genes and Solutions
Many know the frustration of disrupted sleep due to RLS and periodic limb movement disorder (PLMD). Genes play a role in your risk for these disorders, and there are specific research-based treatments to explore.
Explore by Symptoms, Supplements, Diet, or Pathway:
Symptoms
allergies anemia anxiety arthritis blood pressure brain fog depression dysautonomia eyes fatigue gallbladder hair loss heavy menstrual bleeding high blood pressure intestinal issues itching migraine migraines neuropathy pain peripheral nerves POTS sinus skin small fiber neuropathy stress teeth tinnitus tremor
Supplements
Akkermansia muciniphila alpha-ketogluterate alpha-lipoic acid andrographis apigenin ashwagandha astaxanthin astragalus bacopa berberine biotin calcium calcium d-glucurate carnitine cat's claw CBD cinnamon copper CoQ10 cordyceps creatine curcumin d-mannose dihydromyricetin EGCG fisetin fish oil frankincense ginkgo biloba ginseng glycine glycyrrhizin hesperidin inositol iodine l-arginine l-theanine lion's mane lithium orotate lutein luteolin magnesium manganese melatonin methylene blue methylfolate NAC naringenin nattokinase niacin nicotinamide riboside nigella sativa NMN noopept PEA peppermint probiotics quercetin reishi resveratrol rhodiola riboflavin rosemary rosmarinic acid rutin selenium St. Johns wort sulforaphane taurine thiamine TUDCA vitamin A vitamin B12 vitamin B6 vitamin C vitamin D vitamin E vitamin K zinc
Pathways & Processes
acetylcholine AGEs anandamide arachidonic acid autophagy bile acids bone brown fat cannabinoids catecholamines cholesterol circadian rhythm clots cognitive cold collagen complement system connective tissue dopamine endothelium GABA ghrelin glutathione GSTs gut microbiome HbA1c heat shock proteins histamine hypoxia inborn error of metabolism inflammation intelligence klotho lactose lungs macrophages mannose binding lectin mast cells methylation microbiome mitochondria mTOR muscle neurons non-secretor oxidative stress plant sterols platelets pro-resolving mediators senescence serotonin sirtuins T cells taste receptor triglycerides tryptophan tyramine uric acid vagus nerve vascular
Diseases, Conditions
adenovirus ADHD alpha-1 antitrypsin Alzheimer's asthma autism bipolar cancer celiac cystic fibrosis diabetes dry eyes Ehlers-Danlos epilepsy Epstein-Barr virus fibroids fibromyalgia flu gout heart hemochromatosis IBD infertility lupus lyme macular degeneration ME/CFS miscarriage multiple sclerosis NAFLD nickel obesity osteoporosis osteoporsis Parkinson's PCOS periodontal periodontitis Propionibacterium acnes psoriasis rheumatoid arthritis rosacea seasonal affective disorder Sjogren vaccination vaccines virus
Lifestyle & Diet
acupuncture alcohol anthocyanins aspartame athletics caffeine carbs choline coffee corn syrup cruciferous vegetables fasting fiber fodmaps fructose gluten healthspan iron keto light at night liver longevity organic PFOS polyphenols saturated fat sauna sleep
Genes, Proteins
ACE ADAMS adora2a APOE BDNF BH4 CCR5 COMT Covid GLP-1 GSTM1 GSTP1 hemoglobin HLA HMGB1 homocysteine HPA IGF1 IL-13 IL-17 IL-18 IL-1A IL-1B IL-6 interferon-gamma lp(a) MAO NF-kB nitric oxide NLRP3 telomeres TLR4 TNF-alpha TRPV1 UGTs X chromosome
Hormones
Medications
anesthesia antibiotics aspirin CYP450 drugs metformin nicotine NSAIDs psychodelics rapamycin statins
Toxins
Topic: Hormones
- Estrogen: How It Is Made and How We Get Rid of It
Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids. - Hot flashes in menopause: Genetics and natural solutions
Hot flashes affect up to 80% of women going through menopause. Genetics, environment, and diet can make them worse. Target the right solutions. - CYP17A1: Steroid Hormone Production (Testosterone, Estrogen, and DHEA)
CYP17A1 is important in the production of steroid hormones including testosterone and estrogen. SNPs in CYP17A1 impact hormone levels.
Topic: Metabolic Health
- Adenoviruses: Causing Weight Gain and Obesity
There have been several interesting studies linking obesity to a viral infection, specifically an adenovirus. Learn more about this virus and its association with obesity. - Insulin Resistance and Genetics: Finding the Root Cause
Genetics combined with diet causes insulin resistance. While dietary sugar can be involved, genetic research points to BCAAs as having a causal role in IR. - Eating Habits: Snacking and Hunger
Our genes influence our eating habits, often in ways we aren’t consciously aware of! If you are struggling with your eating habits, understanding your genetic variants may give insight into why and how to change your eating for the better.
Topic: Traits
- Dyslexia: Genes + Early Life Stressors
While dyslexia is known to run in families, the role of genetics in dyslexia is still being determined. Here is a quick look at some of the genes involved in dyslexia, affecting around 10% of the population. - Mosquito Bite Genes: Are you a mosquito magnet?
Do you feel like you are a magnet for mosquitoes? Genetic variants do play a role in how attractive you are to mosquitoes. - Will you go bald? Genetics and hair loss
What causes male pattern baldness? A combination of genetics, nutrition, and environmental toxins come together to form the risk factors for baldness. But genetics really seems to rule the roost here.
Topic: Pregnancy / Infertility
- Trying to get pregnant? Targeted Approaches to Improving Egg Quality
Trying to get pregnant? Healthy eggs are vital for a successful pregnancy. Discover four key ways to improve your egg quality, according to research studies. - Folate Optimization: MTHFR and Fertility
MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant. - Genetic Causes of Male Infertility
Almost 10% of couples worldwide struggle with infertility. Learn more about your genetic susceptibility and dig deeper into the lifestyle factors that could affect your sperm.
My Story…
Hi! I’m Debbie Moon. Welcome to Genetic Lifehacks.
When I first had my genetic data sequenced, I was both amazed at the research available in academic journals and frustrated by the difficult language and disconnected topics.
Genetic Lifehacks began as a way to share what I was learning about genetics with my family and friends.
My goal has always been to freely share information so that everyone can benefit.
As the website grew in popularity, I decided that I needed to know more… both more about genetics and more about how the pieces of the biological systems fit together. Since my undergraduate degree was in engineering, I went back to school and received my Master’s degree in Biological Sciences from Clemson University in 2019.
Now a full-time endeavor, Genetic Lifehacks has reached over 2.5 million readers, equipping people to use their genetic data to optimize their health.
~ Debbie Moon, Founder of Genetic Lifehacks