Empowering YOU to Understand Your Genes

Genetic Lifehacks - Information on your genes that you can put into action today.

Welcome to Genetic LifeHacks! The whole point of this blog is to share current research on genetics that you can actually use, breaking down the science into something that you can apply.  Personalized medicine and health information based on your genes will be mainstream…  someday.  Why not make that ‘someday’ become today?  A lot of information …

Too much of a good thing: Mushrooms intolerance and your genes

mushroom_intolerance

I love mushrooms and can eat them in abundance – especially sauteed in a little butter with some salt sprinkled on them!  Yum!  So I was fascinated to read a study that linked mushrooms, a certain gene variant, and Crohn’s disease symptoms. The study, Mushroom intolerance: a novel diet-gene interaction in Crohn’s disease, was published in …

Carbohydrate metabolism: Your genes play a role in insulin and blood glucose levels

Carbs

When it comes to advice about the best diet, the things that everyone seems to accept as gospel don’t always hold true when researchers actually look into them.  Take the glycemic index for example: Around since the 1980’s, accepted dogma holds that white bread will very quickly raise everyone’s blood glucose levels with a GI …

Interaction between high fat diet and ACE deletion

ACE-deletion

Wondering if you should cut down on red meat and fat to lower your blood pressure?  According to a new study, it could depend on your genes. A recent study in the Journal of the American Heart Association illustrates once again the interaction between genetics and diet.  The study looked at blood pressure measurements in …

AMPD1 Deficiency — Varying effects of the polymorphism

AMPD1 Deficiency

Adenosine Monophosphate deaminase is an enzyme coded for by the gene AMPD1 and acts in the skeletal muscles to convert AMP to IMP.  There is one common polymorphism, C34T, that causes a decrease in function of this enzyme.  It is heterozygous in 10% – 15% in Caucasians and Africans, while  ~ 1% are homozygous for …

Diet – Gene Interaction in Type 2 Diabetes Risk

T2DPufa

A new study just came out in the FASEB Journal that looked at the interaction between polyunsaturated fat and the Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-α (PPARGC1A) gene.  The study found that those with the minor allele (C) of rs4235308 combined with a lower PUFA (polyunsaturated fatty acids) to saturated fat ratio cut their risk of type …

Pyruvate Dehydrogenase Deficiency – Mitochondrial disfunction

Pyruvate dehydrogenase is involved in the production of cellular energy in the mitochondria.  It acts as a catalyst in the conversion of pyruvate into acetyl-CoA, which is used in the citric acid cycle (Kreb’s cycle) in cellular respiration and production of ATP. So, it is pretty much essential, and deficiencies of pyruvate dehydrogenase can be …

Choline – An essential nutrient

Choline-An Essential Nutrient

I just finished listening to an interesting podcast featuring Dr. Zeisel, a researcher at the NC Nutrition Research Institute.  The interview discussed the body’s need for choline and the impact of some genetic polymorphisms on our ability to produce it in the body.  So I decided to dig into this a little more and look …

Building Up Iron – Genetics, Diet, and Health Effects

I have blogged before about hemochromatosis and the importance of checking your DNA results for the genetic variants that cause it, but I’m revisiting the topic today with updated research on the topic of iron overload. This is a personal cause for me, and getting the word out to as many people as possible is …

Review of Genos – Whole Exome Sequencing

Genos - Whole Exome Sequencing1

 Genos is a fairly new company in the direct-to-consumer genetic sequencing market.  They offer sequencing of the whole exome, instead of just the specific locations that are covered by services such as 23andMe or AncestryDNA. Moreover, they are bringing in research study partners that then will pay their clients for participating in the studies.  It is …

How our genes shape our gut microbiome and our weight

genes-gut-microbiome

Several studies have come out recently showing that those who are overweight have a different gut microbiome composition than those who are lean.  There have also been interesting mouse studies showing that transplanting feces from obese mice into lean mice causes the lean mice to become obese.  A 2010 study that found that supplementation with the probiotic Lactobacillus …